★★★★★ Trustpilot 4.4|No setup fee to apply

The payment gateway built for UK online pharmacies

eCom Pay is a payment gateway for online pharmacies, with GPhC and MHRA aware onboarding and a dedicated Risk Analyst. Applications are handled by experienced underwriters who understand healthcare and guide you step by step, so a legitimate, registered pharmacy gets approved and live in days, not months.

Supported channels Visa (MCC 5912) Mastercard American Express Apple Pay and Google Pay Open Banking

See if you're pre-approved

Answer a few quick questions for an instant pre-approval indication. No obligation, under 60 seconds.

Pre-approval progress 14%
How do you take payments?
Do you currently take card payments?
What is your industry?
How long have you been trading?
How is your business set up?
Estimated monthly card volume?
Strong match

Based on your answers you are a strong pre-approval match. Confirm a few details and we will finalise your application.

A real person reviews every application, and we never share your data.

24 hrs

approval, once documents are in

150+

currencies processed

4.4

Trustpilot rating

2010

processing payments since

Recently approved: Vape retailerRecently approved: Online pharmacyRecently approved: Dessert and food brandRecently approved: Automotive parts sellerRecently approved: Takeaway and ordering siteRecently approved: Travel agencyRecently approved: CBD storeRecently approved: Forex platformRecently approved: Crypto merchantRecently approved: Subscription boxRecently approved: Salon and bookingsRecently approved: Adult and datingRecently approved: Vape retailerRecently approved: Online pharmacyRecently approved: Dessert and food brandRecently approved: Automotive parts sellerRecently approved: Takeaway and ordering siteRecently approved: Travel agencyRecently approved: CBD storeRecently approved: Forex platformRecently approved: Crypto merchantRecently approved: Subscription boxRecently approved: Salon and bookingsRecently approved: Adult and dating
The problem

Why pharmacy payments need a specialist

It is rarely about your business. An online pharmacy merchant account simply needs deliberate, sector-aware underwriting from the start, and that is a specialism, not a checkbox.

Check your approval odds

Automated risk models

Generic risk models read category codes, not businesses. Prescription only medicines and pharmacy product codes need a human reader who understands GPhC registration and how a legitimate pharmacy actually operates.

Card scheme scrutiny

Visa and Mastercard treat card not present pharmacies under Merchant Category Code 5912 as high risk by default, so a nervous generic acquirer would rather avoid the category than underwrite it properly.

Continuity is everything

When payments stop, patient orders stall, repeat prescriptions miss their window and suppliers go unpaid. A pharmacy needs a payment setup underwritten properly from day one, so trading simply continues.

What matters for a pharmacy Standard gateway eCom Pay specialist flow
Underwriting Automated, sector level decline Human review on healthcare aware acquiring
LegitScript and MCC 5912 Little help, or termination over a compliance gap Hands on help preparing your GPhC, MHRA and website detail for certification
Settlement Delayed payouts, often a rolling reserve Next working day settlement, risk proportionate reserves
Fraud and declines Blunt filters that block real patient orders Calibrated velocity rules, 3D Secure 2 and Open Banking
The fix

Payment processing built for online pharmacies

Every application is read by a person who knows a registered pharmacy is a legitimate business, not a category to avoid. Your account sits on acquiring that deliberately underwrites healthcare, and a real time fraud engine is tuned to stop fraud without blocking a returning patient mid repeat order.

Repeat prescription billing

Patients on long term medication should not re-enter card details every month. We bill repeat scripts automatically with recurring payments, and stored cards are held as secure tokens, never raw card numbers.

Chargeback defence that holds up

Health purchases attract disputes and friendly fraud. We prevent them with 3D Secure 2 and real time fraud screening, then manage any that land. Our guide on how to minimise chargebacks covers the full playbook.

International patients, settled in GBP

Selling to patients overseas should not mean juggling providers. Process in 150 plus currencies, settle in 25 plus, and reconcile everything in one dashboard with next working day settlement.

Plugs into your pharmacy site

Whether you run on WooCommerce, Shopify, Adobe Commerce or a bespoke build, the gateway drops into your existing checkout with hosted payment pages and a full API.

Zero chargeback payment route

For qualifying orders, Open Banking moves money bank to bank with no card network involved, which means no chargebacks at all.

Hosted, tokenised security

Patient card data never touches your server. Hosted payment forms and tokenisation keep you on the right side of PCI DSS, with strong customer authentication built in.

How it works

From rejected to dispensing in four steps

  • Private reviewtell us your pharmacy, your product mix and your volumes. No judgement, no obligation.
  • Application built properlywe present your GPhC registered pharmacy the way underwriters need to see it
  • Specialist acquiringunderwritten deliberately for healthcare and pharmacy
  • Live and protectedfraud rules tuned by your Risk Analyst, chargebacks actively managed
Start your application
Pharmacy application review
Sector: registered pharmacy ✓
Products: POM and P lines ✓ underwritten
History: prior decline ✓ not a barrier
Underwriter: matched ✓
Status: approved
3D Secure 2AI fraud screeningRecurring scriptsOpen Banking
Rated 4.4 on Trustpilot

What our merchants say

Fair. So here is what UK merchants say after switching to eCom Pay, in their own words.

★★★★★

No hidden fees, best so far

It was such a pleasure working with eCom Pay for my company, very straightforward to set up and the team were so helpful. No hidden fees, cost efficient, and from using other platforms before I can say this has been the best so far.

Verified merchantvia Trustpilot

★★★★★

Simpler than the big names

We found eCom Pay to be a simple, efficient payment system to integrate, with a lot of support behind it. Would recommend them over competitors who charge far too much.

Verified merchantvia Trustpilot

★★★★★

Set up fast, better rates

Great customer service from eCom Pay. Needed a card reader for my business, they had me set up fast and gave me better rates than the last company. Highly recommend.

Verified merchantvia Trustpilot

★★★★★

Sales noticeably improved

Super impressed with eCom Pay. The transaction fees are competitive, and I love that my customers have multiple payment options, which has noticeably improved my sales.

Verified merchantvia Trustpilot

★★★★★

Transparent, reliable, efficient

Good service from eCom Pay. The card machines are reliable and easy to use. I like that there are no hidden fees and everything is explained upfront.

Verified merchantvia Trustpilot

★★★★★

Always answers when I need help

Would highly recommend. Easy, simple, and always answers when I need help. The best payment gateway I have come across, with a wide variety of packages available.

Verified merchantvia Trustpilot

Compliance

The compliance side, handled properly

You operate under real oversight, and underwriters know it. We are not the regulator and we do not advise on clinical matters. What we do is make the payment side line up with the regulated side.

GPhC and MHRA registration

Underwriters want to see a pharmacy registered with the General Pharmaceutical Council and the MHRA distance selling logo where required. Meeting that bar makes you a stronger applicant, not a weaker one.

LegitScript and MCC 5912

Visa and Mastercard recognise third party certification such as LegitScript for card not present pharmacies under MCC 5912. We are not the certifier, but we help prepare your records and website so the review runs in parallel with acquiring.

Age, identity and adjacent lines

The checkout supports the age and identity checks your model needs, with strong customer authentication throughout. Adjacent regulated lines such as CBD and supplements sit on the same account.

Who we work with

Built for every kind of online pharmacy

No two pharmacy models look the same to an underwriter, and a gateway that only understands one of them is no use to you. We take payments across all of these.

Distance selling pharmacy Online doctor and pharmacy High street plus web shop Repeat dispensing Travel and vaccination clinics Weight management and wellness

Whatever your platform, the gateway fits it rather than the other way round. There is a developer first plugin for WooCommerce pharmacy checkouts, a flexible route for Shopify when Shopify Payments will not support medicine sales, and a full REST API for bespoke online doctor builds. Hosted payment pages keep card data off your own servers throughout.

WooCommerce Shopify Adobe Commerce OpenCart Custom REST API
Approval checklist

What underwriters want to see from a pharmacy

Present these well and approval is straightforward. We help you pull them together before the application goes in, so it lands right the first time rather than coming back with questions.

  • GPhC registrationyour registered pharmacy number and responsible pharmacist on record
  • MHRA distance selling statusthe registration and logo where your selling model requires it
  • A clear prescribing modelhow a prescription is generated, checked and fulfilled
  • Trading detailprojected volumes, average order value, suppliers and your refund policy
Start your application
Onboarding checklist
GPhC registration ✓
MHRA logo where required ✓
LegitScript prep underway ✓
Volumes and AOV provided ✓
Outcome: ready to submit
Experienced underwritersReal reviewSpecialist acquiring
Cash flow

Settled on time, with a clean audit trail

Cash flow is the lifeblood of a pharmacy, and it deserves an underwriting approach built for the sector from day one. Here is ours.

Next working day settlement

High risk accounts are often saddled with long delays or rolling reserves that lock up your takings. We settle next working day and size any reserve around your real trading history, not a category label.

A clean audit trail

Every transaction is traceable and every refund and dispute is logged. For phone and prescription line orders, a virtual terminal and Pay by Link take payment with full 3D Secure authentication.

International patients

Process in over 150 currencies and let patients pay in their own while you settle in over 25. Local payment methods and Open Banking widen acceptance, and everything reconciles back to one clear view.

Chargebacks

How we keep pharmacy chargebacks down

Disputes are not solved with a single tool. We work them in four layers, from prevention through to managing the ones that still land.

01

Prevent

3D Secure 2 authenticates the cardholder and shifts fraud liability away from you, while a real time fraud engine screens transactions and is tuned to avoid false declines that cost you genuine patient orders.

02

Eliminate

For qualifying orders, Open Banking takes the card network out of the equation. No card, no chargeback, with strong authentication handled inside the banking app.

03

Reduce the root cause

Tokenisation replaces stored card data with a meaningless token, so repeat prescription billing is seamless and far less exposed to the fraud that drives disputes in the first place.

04

Manage

When a chargeback does land, dispute tools sit in your dashboard and your Risk Analyst helps you respond with evidence. See our guides on minimising chargebacks and fraud prevention.

Online pharmacy payment gateway
FAQs

Online pharmacy payments, straight answers

Can I get a payment gateway for my online pharmacy in the UK?

Yes. A registered UK online pharmacy can get a dedicated pharmacy payment gateway and merchant account through eCom Pay. Our specialist acquiring underwrites healthcare deliberately, with human review rather than an automated decline, so legitimate pharmacies get approved.

Why do payment providers class pharmacies as high risk?

It is the products, not your business. Automated risk models flag prescription only medicines, pharmacy product codes and healthcare merchant categories by default, and the card schemes monitor the sector closely. A legitimate, GPhC registered pharmacy ends up labelled high risk simply by association.

Do I need to be GPhC registered to get a pharmacy merchant account?

For a UK online pharmacy, yes. Underwriters expect registration with the General Pharmaceutical Council and the MHRA distance selling logo where it applies. Meeting that bar makes you a stronger applicant. We help present your registered pharmacy the way underwriters need to see it.

What is LegitScript certification, and is it required for Visa and Mastercard processing?

Visa and Mastercard treat card not present pharmacies under Merchant Category Code 5912 as high risk and recognise third party certification such as LegitScript as part of that registration. We are not the certifier, but we help prepare your regulatory and website detail so the review goes smoothly.

Can you process payments for prescription only medicines?

Yes, for appropriately registered pharmacies dispensing within their regulatory permissions. We are a payment company, so the clinical and prescribing side stays with you and your regulator, while we make the payment processing line up with how a compliant pharmacy operates.

How do you handle repeat prescription billing?

Through recurring payments and tokenisation. Patients on long term medication are billed automatically on a schedule, with their card held as a secure token rather than raw data. It means no re-entering details each month and a smoother, lower friction repeat order.

I have been declined before. Can you still help?

Yes, and most pharmacies that come to us have been declined or offboarded elsewhere. A previous decline usually reflects a poorly presented application, not a problem with your pharmacy. We process the application again properly and place it correctly.

How quickly can my online pharmacy be approved and live?

Straightforward cases complete in a few working days. Heavily regulated setups can take a little longer because underwriters review documentation properly. We manage that process for you throughout and keep you updated rather than leaving you chasing.

Do you support international and multi-currency pharmacy sales?

Yes. You can process in over 150 currencies and settle in over 25, with reconciliation in a single dashboard and next working day settlement. Patients abroad pay in their own currency while you keep one clean view of every transaction.

Written by the eCom Pay team. Reviewed August 2026. Last updated August 2026.

Your pharmacy deserves a payment partner that understands it properly.

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